[Rushtalk] Scientists find DNA differences between gay men and their straight twin brothers

Dennis Putnam dap1 at bellsouth.net
Tue Nov 10 05:21:31 MST 2015


Agree. If it is genetic the homosexual community will go ballistic if
anyone suggests research to find a cure.

On 11/9/2015 9:35 PM, Stephen A. Frye wrote:
>
> Of course you think it’s a fraud.  If it turns out to be anything
> other than 100% free choice, it hurts our whole perspective.
>
>  
>
> Science be damned – full speed ahead!
>
>  
>
> *From:*rushtalk-bounces at csdco.com [mailto:rushtalk-bounces at csdco.com]
> *On Behalf Of *John A. Quayle
> *Sent:* Monday, November 09, 2015 4:50 PM
> *To:* Rushtalk Discussion List; Rushtalk
> *Subject:* Re: [Rushtalk] Scientists find DNA differences between gay
> men and their straight twin brothers
>
>  
>
>          */_IF_/**/this is true (and I'm thinking it's a complete
> fraud), the God's got some apologizing to do those who lived in
> ancient Sodom and Gomorrah.................    - jaq
>
>
>
>
> /*At 03:25 PM 11/8/2015, Carl Spitzer wrote:
>
>
>
>  
>
>
>   Scientists find DNA differences between gay men and their straight
>   twin brothers
>   <http://www.latimes.com/science/sciencenow/la-sci-sn-genetic-homosexuality-nature-nurture-20151007-story.html>
>
>
>
>
> Homosexuality epigenome markers Could the molecular signals that turn
> genes on and off reveal a person's sexual orientation? New research
> identifies epigenomic "marks" linked to homosexuality. But experts say
> the origins of partner preference remain a mystery.
>
> (Chuck Nigash ,Stephen Sedam / Los Angeles Times) Melissa HealyMelissa
> Healy
> <http://www.latimes.com/la-bio-melissa-healy-staff.html#navtype=byline>
> For men, new research suggests that clues to sexual orientation may
> lie not just in the genes, but in the spaces between the DNA, where
> molecular marks instruct genes when to turn on and off and how
> strongly to express themselves.
>
> On Thursday, UCLA molecular biologist Tuck C. Ngun
> <http://gendercenter.genetics.ucla.edu/proj-genetics-sexual-orientation>reported
> that in studying the genetic material of 47 pairs of identical male
> twins, he has identified "epigenetic marks" in nine areas of the human
> genome that are strongly linked to male homosexuality.
>
> In individuals, said Ngun, the presence of these distinct molecular
> marks can predict homosexuality with an accuracy of close to 70%.
>
>
> That news, presented at the 2015 meeting of the American Society of
> Human Genetics on Thursday, may leave the genetically uninitiated
> scratching their heads.
>
> But experts said the results -- as yet unpublished in a peer-reviewed
> journal -- offer preliminary new evidence that a man's genetic
> inheritance is only one influence on his sexual orientation. Through
> the epigenome, the results suggest, some facet of life experience
> likely also primes a man for same-sex attraction.
>
> DNA from 4,500-year-old Ethiopian reveals surprise about ancest
> <http://www.latimes.com/science/sciencenow/la-sci-sn-ancient-ethiopian-dna-eurasia-20151008-story.html> DNA
> from 4,500-year-old Ethiopian reveals surprise about ancestry of
> Africans
> <http://www.latimes.com/science/sciencenow/la-sci-sn-ancient-ethiopian-dna-eurasia-20151008-story.html>
> Over a person's lifetime, myriad environmental factors -- nutrition,
> poverty, a mother's love, education, exposure to toxic chemicals --
> all help shape the person he will become.
>
> Researchers working in the young science of epigenetics acknowledge
> they are unsure just how an individual's epigenome is formed. But they
> increasingly suspect it is forged, in part, by the stresses and
> demands of external influences. A set of chemical marks that lies
> between the genes, the epigenome changes the function of genetic
> material, turning the human body's roughly 20,000 protein-coding genes
> on or off in response to the needs of the moment.
>
>
>
> While genes rarely change over a lifetime, the epigenome is constantly
> changing.
>
> Geneticists suggest that together, the human genome and its epigenome
> reflect the interaction of nature and nurture -- both our fixed
> inheritance and our bodies' flexible responses to the world -- in
> making us who we are.
>
> Ngun's study of twins doesn't reveal how or when a male takes on the
> epigenomic marks that distinguish him as homosexual. Many researchers
> believe that a person's eventual sexual preferences are shaped in the
> uterus
> <http://articles.latimes.com/2006/jun/27/science/sci-brothers27>, by
> hormonal shifts during key stages of fetal brain development.
>
> *FROM THE ARCHIVES: A closer look at scientific inquiry into sexual
> orientation <http://articles.latimes.com/2001/may/21/health/he-533>*
>
> By imprinting themselves on the epigenome, though, environmental
> influences may powerfully affect how an individual's genes express
> themselves over the course of his life. Ngun's findings suggest they
> may interact with genes to nudge sexual orientation in one direction
> or the other.
>
> "The relative contributions of biology versus culture and experience
> in shaping sexual orientation in humans continues to be debated," said
> University of Maryland pharmacology professor Margaret M. McCarthy,
> who was not involved in the current study. "But regardless of when, or
> even how, these epigenetic changes occur," she added, the new research
> "demonstrates a biological basis to partner preference."
>
> To find the epigenomic markers of male homosexuality, Ngun, a
> postdoctoral researcher at UCLA's Geffen School of Medicine, combed
> through the genetic material of 47 sets of identical male twins.
> Thirty-seven of those twin sets were pairs in which one was homosexual
> and the other was heterosexual. In 10 of the pairs studied, both twins
> identified as homosexual.
>
> In identical twins, DNA is shared and overlaps perfectly. But the
> existence of twin pairs in which one is homosexual and the other is
> not offers strong evidence that something other than DNA alone
> influences sexual orientation. Ngun and his colleagues looked for
> patterns of DNA methylation -- the chemical process by which the
> epigenome is encoded -- to identify the missing factor in partner
> preference.
>
> Their analysis generated a dataset far too large for a team of humans
> to make sense of. So they unleashed a machine learning algorithm on
> the data to search for regularities that distinguished the epigenomes
> of homosexual twin-pairs from twins in which only one was homosexual.
>
> In nine compact regions scattered across the genome, they found
> patterns of epigenomic differences that would allow a prediction far
> more accurate than a random guess of an individual's sexual
> orientation, Ngun reported Thursday.
>
> McCarthy and other experts cautioned that the discovery of epigenomic
> marks suggestive of homosexuality is a far cry from finding the causes
> of sexual preference.
>
> The distinctive epigenomic marks observed by Ngun and his colleagues
> could result from some other biological or lifestyle factor common to
> homosexual men but unrelated to their sexuality, said University of
> Utah geneticist Christopher Gregg. They could correlate with
> homosexuality but have nothing to do with it.
>
> “Epigenetic marks are the consequence of complex interactions between
> the genetics, development and environment of an individual," said
> University of Cambridge geneticist Eric Miska. "Simple correlations --
> if significant -- of epigenetic marks of an individual with anything
> from favorite football player to disease risk does not imply a causal
> relationship or understanding.”
>
> One longtime researcher in the field of sexual orientation praised
> Ngun’s use of identical twins as a means of teasing apart the various
> biological factors that influence the trait.
>
> “Our best guess is that there are genes” that affect a man’s sexual
> orientation “because that’s what twin studies suggest,” said
> Northwestern University psychologist J. Michael Bailey, who  has
> explored a range of physiological markers that point to
> homosexuality’s origins in the womb. But the existence of identical
> twin pairs in which only one is homosexual “conclusively suggest that
> genes don’t explain everything,” Bailey added.
>
> While Ngun’s research needs to be replicated in larger studies of
> twins, it advances the fitful process of better understanding how ­
> and when ­ a boy’s sexual orientation develops, Bailey said.
>
> *Follow me on Twitter @LATMelissaHealy
> <https://twitter.com/LATMelissaHealy> and "like" Los Angeles Times
> Science & Health <https://www.facebook.com/latimesscience> on Facebook.*
>
>
>
> __._,_.___
>
>
> So why not test for it and adjust insurance premiums according to risk??
> CWSIV
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