[Rushtalk] Scientists find DNA differences between gay men and their straight twin brothers

Dennis Putnam dap1 at bellsouth.net
Tue Nov 10 07:59:14 MST 2015


That was odd. How about this time?

On 11/10/2015 8:55 AM, Dennis Putnam wrote:
> Again I agree but that also does not preclude the possibility of a
> cure any more than research for curing Downs Syndrome. To which no one
> objects as far as I know. The issue is that homosexuals can't have it
> both ways and researching a potential genetic cure should not cause
> them to go into a homophobic rage.
>
> On 11/10/2015 8:48 AM, Stephen A. Frye wrote:
>>
>> And .. even if it is genetic, that doesn’t imply that there is a cure
>> any more than there is a “cure” for blue eyes.  It simply identifies
>> a possible cause.
>>
>>  
>>
>> *From:*rushtalk-bounces at csdco.com [mailto:rushtalk-bounces at csdco.com]
>> *On Behalf Of *Dennis Putnam
>> *Sent:* Tuesday, November 10, 2015 4:22 AM
>> *To:* rushtalk at csdco.com
>> *Subject:* Re: [Rushtalk] Scientists find DNA differences between gay
>> men and their straight twin brothers
>>
>>  
>>
>> Agree. If it is genetic the homosexual community will go ballistic if
>> anyone suggests research to find a cure.
>>
>> On 11/9/2015 9:35 PM, Stephen A. Frye wrote:
>>
>>     Of course you think it’s a fraud.  If it turns out to be anything
>>     other than 100% free choice, it hurts our whole perspective.
>>
>>      
>>
>>     Science be damned – full speed ahead!
>>
>>      
>>
>>     *From:*rushtalk-bounces at csdco.com
>>     <mailto:rushtalk-bounces at csdco.com>
>>     [mailto:rushtalk-bounces at csdco.com] *On Behalf Of *John A. Quayle
>>     *Sent:* Monday, November 09, 2015 4:50 PM
>>     *To:* Rushtalk Discussion List; Rushtalk
>>     *Subject:* Re: [Rushtalk] Scientists find DNA differences between
>>     gay men and their straight twin brothers
>>
>>      
>>
>>              */_IF_/**/this is true (and I'm thinking it's a complete
>>     fraud), the God's got some apologizing to do those who lived in
>>     ancient Sodom and Gomorrah.................    - jaq
>>
>>
>>
>>
>>     /*At 03:25 PM 11/8/2015, Carl Spitzer wrote:
>>
>>
>>
>>
>>      
>>
>>
>>       Scientists find DNA differences between gay men and their
>>       straight twin brothers
>>       <http://www.latimes.com/science/sciencenow/la-sci-sn-genetic-homosexuality-nature-nurture-20151007-story.html>
>>
>>
>>
>>
>>     Homosexuality epigenome markers Could the molecular signals that
>>     turn genes on and off reveal a person's sexual orientation? New
>>     research identifies epigenomic "marks" linked to homosexuality.
>>     But experts say the origins of partner preference remain a mystery.
>>
>>     (Chuck Nigash ,Stephen Sedam / Los Angeles Times) Melissa
>>     HealyMelissa Healy
>>     <http://www.latimes.com/la-bio-melissa-healy-staff.html#navtype=byline>
>>
>>     For men, new research suggests that clues to sexual orientation
>>     may lie not just in the genes, but in the spaces between the DNA,
>>     where molecular marks instruct genes when to turn on and off and
>>     how strongly to express themselves.
>>
>>     On Thursday, UCLA molecular biologist Tuck C. Ngun
>>     <http://gendercenter.genetics.ucla.edu/proj-genetics-sexual-orientation>reported
>>     that in studying the genetic material of 47 pairs of identical
>>     male twins, he has identified "epigenetic marks" in nine areas of
>>     the human genome that are strongly linked to male homosexuality.
>>
>>     In individuals, said Ngun, the presence of these distinct
>>     molecular marks can predict homosexuality with an accuracy of
>>     close to 70%.
>>
>>
>>     That news, presented at the 2015 meeting of the American Society
>>     of Human Genetics on Thursday, may leave the genetically
>>     uninitiated scratching their heads.
>>
>>     But experts said the results -- as yet unpublished in a
>>     peer-reviewed journal -- offer preliminary new evidence that a
>>     man's genetic inheritance is only one influence on his sexual
>>     orientation. Through the epigenome, the results suggest, some
>>     facet of life experience likely also primes a man for same-sex
>>     attraction.
>>
>>     DNA from 4,500-year-old Ethiopian reveals surprise about ancest
>>     <http://www.latimes.com/science/sciencenow/la-sci-sn-ancient-ethiopian-dna-eurasia-20151008-story.html> DNA
>>     from 4,500-year-old Ethiopian reveals surprise about ancestry of
>>     Africans
>>     <http://www.latimes.com/science/sciencenow/la-sci-sn-ancient-ethiopian-dna-eurasia-20151008-story.html>
>>     Over a person's lifetime, myriad environmental factors --
>>     nutrition, poverty, a mother's love, education, exposure to toxic
>>     chemicals -- all help shape the person he will become.
>>
>>     Researchers working in the young science of epigenetics
>>     acknowledge they are unsure just how an individual's epigenome is
>>     formed. But they increasingly suspect it is forged, in part, by
>>     the stresses and demands of external influences. A set of
>>     chemical marks that lies between the genes, the epigenome changes
>>     the function of genetic material, turning the human body's
>>     roughly 20,000 protein-coding genes on or off in response to the
>>     needs of the moment.
>>
>>
>>
>>     While genes rarely change over a lifetime, the epigenome is
>>     constantly changing.
>>
>>     Geneticists suggest that together, the human genome and its
>>     epigenome reflect the interaction of nature and nurture -- both
>>     our fixed inheritance and our bodies' flexible responses to the
>>     world -- in making us who we are.
>>
>>     Ngun's study of twins doesn't reveal how or when a male takes on
>>     the epigenomic marks that distinguish him as homosexual. Many
>>     researchers believe that a person's eventual sexual preferences
>>     are shaped in the uterus
>>     <http://articles.latimes.com/2006/jun/27/science/sci-brothers27>,
>>     by hormonal shifts during key stages of fetal brain development.
>>
>>     *FROM THE ARCHIVES: A closer look at scientific inquiry into
>>     sexual orientation
>>     <http://articles.latimes.com/2001/may/21/health/he-533>*
>>
>>     By imprinting themselves on the epigenome, though, environmental
>>     influences may powerfully affect how an individual's genes
>>     express themselves over the course of his life. Ngun's findings
>>     suggest they may interact with genes to nudge sexual orientation
>>     in one direction or the other.
>>
>>     "The relative contributions of biology versus culture and
>>     experience in shaping sexual orientation in humans continues to
>>     be debated," said University of Maryland pharmacology professor
>>     Margaret M. McCarthy, who was not involved in the current study.
>>     "But regardless of when, or even how, these epigenetic changes
>>     occur," she added, the new research "demonstrates a biological
>>     basis to partner preference."
>>
>>     To find the epigenomic markers of male homosexuality, Ngun, a
>>     postdoctoral researcher at UCLA's Geffen School of Medicine,
>>     combed through the genetic material of 47 sets of identical male
>>     twins. Thirty-seven of those twin sets were pairs in which one
>>     was homosexual and the other was heterosexual. In 10 of the pairs
>>     studied, both twins identified as homosexual.
>>
>>     In identical twins, DNA is shared and overlaps perfectly. But the
>>     existence of twin pairs in which one is homosexual and the other
>>     is not offers strong evidence that something other than DNA alone
>>     influences sexual orientation. Ngun and his colleagues looked for
>>     patterns of DNA methylation -- the chemical process by which the
>>     epigenome is encoded -- to identify the missing factor in partner
>>     preference.
>>
>>     Their analysis generated a dataset far too large for a team of
>>     humans to make sense of. So they unleashed a machine learning
>>     algorithm on the data to search for regularities that
>>     distinguished the epigenomes of homosexual twin-pairs from twins
>>     in which only one was homosexual.
>>
>>     In nine compact regions scattered across the genome, they found
>>     patterns of epigenomic differences that would allow a prediction
>>     far more accurate than a random guess of an individual's sexual
>>     orientation, Ngun reported Thursday.
>>
>>     McCarthy and other experts cautioned that the discovery of
>>     epigenomic marks suggestive of homosexuality is a far cry from
>>     finding the causes of sexual preference.
>>
>>     The distinctive epigenomic marks observed by Ngun and his
>>     colleagues could result from some other biological or lifestyle
>>     factor common to homosexual men but unrelated to their sexuality,
>>     said University of Utah geneticist Christopher Gregg. They could
>>     correlate with homosexuality but have nothing to do with it.
>>
>>     “Epigenetic marks are the consequence of complex interactions
>>     between the genetics, development and environment of an
>>     individual," said University of Cambridge geneticist Eric Miska.
>>     "Simple correlations -- if significant -- of epigenetic marks of
>>     an individual with anything from favorite football player to
>>     disease risk does not imply a causal relationship or understanding.”
>>
>>     One longtime researcher in the field of sexual orientation
>>     praised Ngun’s use of identical twins as a means of teasing apart
>>     the various biological factors that influence the trait.
>>
>>     “Our best guess is that there are genes” that affect a man’s
>>     sexual orientation “because that’s what twin studies suggest,”
>>     said Northwestern University psychologist J. Michael Bailey, who 
>>     has explored a range of physiological markers that point to
>>     homosexuality’s origins in the womb. But the existence of
>>     identical twin pairs in which only one is homosexual
>>     “conclusively suggest that genes don’t explain everything,”
>>     Bailey added.
>>
>>     While Ngun’s research needs to be replicated in larger studies of
>>     twins, it advances the fitful process of better understanding how
>>     ­ and when ­ a boy’s sexual orientation develops, Bailey said.
>>
>>     *Follow me on Twitter @LATMelissaHealy
>>     <https://twitter.com/LATMelissaHealy> and "like" Los Angeles
>>     Times Science & Health <https://www.facebook.com/latimesscience>
>>     on Facebook.*
>>
>>
>>
>>     __._,_.___
>>
>>
>>     So why not test for it and adjust insurance premiums according to
>>     risk??
>>     CWSIV
>>     _______________________________________________
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>>
>>
>>
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>>  
>>
>>
>>
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