[Rushtalk] Scientists find DNA differences between gay men and their straight twin brothers

John A. Quayle blueoval57 at verizon.net
Wed Nov 11 04:42:03 MST 2015


It’s Science You Bigots. They Want You To Believe She Was Born That Way.

This is becoming a trend. Some parents want their 
little girl referred to as a boy in school. A 
6-year-old transgender student at a Katy daycare 
has sparked quite a discussion about how the 
school should address the issue with the child’s 
classmates. Two employees who disagreed with the 
way the private school owners 
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Like Its Science You Bigots. They Want You To Believe Sh

At 08:45 AM 11/10/2015, you wrote:

>I am always a skeptic, but 

>I notice over the years that we like science a 
>lot when it agrees with our politics, and we don’t like it when it disagrees.
>It’s very difficult to separate science from 
>politics, as we enter the debate with a bias.  As do our opponents.
>From: rushtalk-bounces at csdco.com 
>[mailto:rushtalk-bounces at csdco.com] On Behalf Of John A. Quayle
>Sent: Monday, November 09, 2015 6:41 PM
>To: Rushtalk Discussion List; 'Rushtalk Discussion List'
>Subject: Re: [Rushtalk] Scientists find DNA 
>differences between gay men and their straight twin brothers
>At 09:35 PM 11/9/2015, Stephen A. Frye wrote:
>Of course you think it’s a fraud.  If it turns 
>out to be anything other than 100% free choice, it hurts our whole perspective.
>Science be damned – full speed ahead!
>          Hang on a sec, Stephen........look how 
> "Science" has been manipulated with regard to globalwarming/cooling.....
><mailto:rushtalk-bounces at csdco.com>rushtalk-bounces at csdco.com 
>[ mailto:rushtalk-bounces at csdco.com] On Behalf Of John A. Quayle
>Sent: Monday, November 09, 2015 4:50 PM
>To: Rushtalk Discussion List; Rushtalk
>Subject: Re: [Rushtalk] Scientists find DNA 
>differences between gay men and their straight twin brothers
>          IF this is true (and I'm thinking it's 
> a complete fraud), the God's got some 
> apologizing to do those who lived in ancient 
> Sodom and Gomorrah.................    - jaq
>At 03:25 PM 11/8/2015, Carl Spitzer wrote:
>find DNA differences between gay men and their straight twin brothers
>Homosexuality epigenome markers
>  Could the molecular signals that turn genes on 
> and off reveal a person's sexual orientation? 
> New research identifies epigenomic "marks" 
> linked to homosexuality. But experts say the 
> origins of partner preference remain a mystery.
>(Chuck Nigash ,Stephen Sedam / Los Angeles Times)
>Melissa Healy
>For men, new research suggests that clues to 
>sexual orientation may lie not just in the 
>genes, but in the spaces between the DNA, where 
>molecular marks instruct genes when to turn on 
>and off and how strongly to express themselves.
>On Thursday, 
>molecular biologist Tuck C. Ngun reported that 
>in studying the genetic material of 47 pairs of 
>identical male twins, he has identified 
>"epigenetic marks" in nine areas of the human 
>genome that are strongly linked to male homosexuality.
>In individuals, said Ngun, the presence of these 
>distinct molecular marks can predict 
>homosexuality with an accuracy of close to 70%.
>That news, presented at the 2015 meeting of the 
>American Society of Human Genetics on Thursday, 
>may leave the genetically uninitiated scratching their heads.
>But experts said the results -- as yet 
>unpublished in a peer-reviewed journal -- offer 
>preliminary new evidence that a man's genetic 
>inheritance is only one influence on his sexual 
>orientation. Through the epigenome, the results 
>suggest, some facet of life experience likely 
>also primes a man for same-sex attraction.
>DNA from 4,500-year-old Ethiopian reveals surprise about ancest
>DNA from 4,500-year-old Ethiopian reveals 
>surprise about ancestry of Africans Over a 
>person's lifetime, myriad environmental factors 
>-- nutrition, poverty, a mother's love, 
>education, exposure to toxic chemicals -- all 
>help shape the person he will become.
>Researchers working in the young science of 
>epigenetics acknowledge they are unsure just how 
>an individual's epigenome is formed. But they 
>increasingly suspect it is forged, in part, by 
>the stresses and demands of external influences. 
>A set of chemical marks that lies between the 
>genes, the epigenome changes the function of 
>genetic material, turning the human body's 
>roughly 20,000 protein-coding genes on or off in 
>response to the needs of the moment.
>While genes rarely change over a lifetime, the 
>epigenome is constantly changing.
>Geneticists suggest that together, the human 
>genome and its epigenome reflect the interaction 
>of nature and nurture -- both our fixed 
>inheritance and our bodies' flexible responses 
>to the world -- in making us who we are.
>Ngun's study of twins doesn't reveal how or when 
>a male takes on the epigenomic marks that 
>distinguish him as homosexual. Many researchers 
>believe that a person's eventual sexual 
>preferences are 
>in the uterus, by hormonal shifts during key stages of fetal brain development.
>THE ARCHIVES: A closer look at scientific inquiry into sexual orientation
>By imprinting themselves on the epigenome, 
>though, environmental influences may powerfully 
>affect how an individual's genes express 
>themselves over the course of his life. Ngun's 
>findings suggest they may interact with genes to 
>nudge sexual orientation in one direction or the other.
>"The relative contributions of biology versus 
>culture and experience in shaping sexual 
>orientation in humans continues to be debated," 
>said University of Maryland pharmacology 
>professor Margaret M. McCarthy, who was not 
>involved in the current study. "But regardless 
>of when, or even how, these epigenetic changes 
>occur," she added, the new research 
>"demonstrates a biological basis to partner preference."
>To find the epigenomic markers of male 
>homosexuality, Ngun, a postdoctoral researcher 
>at UCLA's Geffen School of Medicine, combed 
>through the genetic material of 47 sets of 
>identical male twins. Thirty-seven of those twin 
>sets were pairs in which one was homosexual and 
>the other was heterosexual. In 10 of the pairs 
>studied, both twins identified as homosexual.
>In identical twins, DNA is shared and overlaps 
>perfectly. But the existence of twin pairs in 
>which one is homosexual and the other is not 
>offers strong evidence that something other than 
>DNA alone influences sexual orientation. Ngun 
>and his colleagues looked for patterns of DNA 
>methylation -- the chemical process by which the 
>epigenome is encoded -- to identify the missing factor in partner preference.
>Their analysis generated a dataset far too large 
>for a team of humans to make sense of. So they 
>unleashed a machine learning algorithm on the 
>data to search for regularities that 
>distinguished the epigenomes of homosexual 
>twin-pairs from twins in which only one was homosexual.
>In nine compact regions scattered across the 
>genome, they found patterns of epigenomic 
>differences that would allow a prediction far 
>more accurate than a random guess of an 
>individual's sexual orientation, Ngun reported Thursday.
>McCarthy and other experts cautioned that the 
>discovery of epigenomic marks suggestive of 
>homosexuality is a far cry from finding the causes of sexual preference.
>The distinctive epigenomic marks observed by 
>Ngun and his colleagues could result from some 
>other biological or lifestyle factor common to 
>homosexual men but unrelated to their sexuality, 
>said University of Utah geneticist Christopher 
>Gregg. They could correlate with homosexuality but have nothing to do with it.
>“Epigenetic marks are the consequence of complex 
>interactions between the genetics, development 
>and environment of an individual," said 
>University of Cambridge geneticist Eric Miska. 
>"Simple correlations -- if significant -- of 
>epigenetic marks of an individual with anything 
>from favorite football player to disease risk 
>does not imply a causal relationship or understanding.”
>One longtime researcher in the field of sexual 
>orientation praised Ngun’s use of identical 
>twins as a means of teasing apart the various 
>biological factors that influence the trait.
>“Our best guess is that there are genes” that 
>affect a man’s sexual orientation “because 
>that’s what twin studies suggest,” said 
>Northwestern University psychologist J. Michael 
>Bailey, who  has explored a range of 
>physiological markers that point to 
>homosexuality’s origins in the womb. But the 
>existence of identical twin pairs in which only 
>one is homosexual “conclusively suggest that 
>genes don’t explain everything,” Bailey added.
>While Ngun’s research needs to be replicated in 
>larger studies of twins, it advances the fitful 
>process of better understanding how ­ and when ­ 
>a boy’s sexual orientation develops, Bailey said.
>Follow me on Twitter 
>and "like" 
>Angeles Times Science & Health on Facebook.
>So why not test for it and adjust insurance premiums according to risk??
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